I run a, now older, i74770K overclocked to 4.4, with 2.5 TB of SSD drives and 8TB of HDDs, and 32Gb RAM. OS is on a dedicated SSD. 16Gb of RAM are dedicated to a virtual RAM drive as soon as my computer boots and I use that along with swap disk on a dedicated SSD. I don't remember the number off hand, but I get a pretty good score on PI's test, but I do not think that test has a lot of relevancy to real world PI use. What I found was that the RAM drive did help, but not in many operations. My video card is a mediocre 4Gb NVIDA card, but I don't think video acceleration is lacking. What I have seen is that processes (virtually all of them) are faster at 4.4Ghz than they are at 3.8 (or so), and, not surprisingly, everything runs faster off SSDs. To me that means that CPU speed matters, RAM drives help, SSDs are critical, and video cards are not critical (I only compared to a lower level card). I have tried lots of combinations of sawp drives with SSDs and RAM drives, different CPU speeds, etc. I've tested a lot of permutations of my system. My next upgrade will be for a faster CPU, but perhaps more importantly, a 6 or 8 core CPU as I think others have demonstrated that more cores at a given speed are faster.
Also, I too am processing 150-300 (or more) ASI1600 NB images at a time. I find that my current system is pretty fast on all processes, and very much faster than is used to be at stock clock, no RAM drive, 16Gb RAM, and HDDs. In fact it's fast enough that I am in no hurry to upgrade.
Larry