The SNR of target structures in a calibrated frame can never exceed the SNR of the master flat.
An SNR of several hundred is typically "good enough" for the brightest structures.
So to be conservative, pick say 500 as master flat SNR. This requires 500^2 = 250,000 e- total in the master. For your detector, one flat exposure at 50% is 30,000 e-. So 250,000 / 30,000 = 8 flat exposures are required.
Regards,
Mike
PS: Some high-end folks like 1000 SNR for the master flat. Seems a bit overkill, would require ~32 exposures.