PixInsight 1.8.4 fully supports high-density displays, including Apple Retina, 4K, 5K and 8K displays, on all supported platforms.
As for Dell computers, there is a problem with Dell's utility software on Windows. See
this thread for more information. Basically, if you really insist in using Windows, my strong recommendation is to reinstall a clean copy of the operating system without
any utility software from Dell.
As for SSD / more RAM, I have little to add to what Mike has already said: use both.