Jim,
Yes, if you capture just at sky limit. One option to reduce # cals is to expose longer so read and cal noise are even further buried by the larger sky noise.
On flats, I am not sure. At least two issues, their "flatness" and their SNR.
My panel flats are not truly "flat" (spec is 1%, that might be optimistic), but on my Ha neb fields it is not really possible to model a gradient, so I don't DBE.
Flat SNR shouldn't limit target SNR, but I think target SNR's more than say a couple hundred are not really necessary. So pick flat SNR say 400. That requires 160,000 e-. My camera full-well is 25,000 e-, expose at ~50%, say 10,000 e- per flat frame. So 16 frames are needed.
Thanks,
Mike