ImageIntegration, per se, can do some fancy statistics to determine the value to assign to each pixel (e.g., Winzorized Mean). From just two images, however, about the only relevant statistic one can compute is the mean (average). If you align the two images (using DynamicAlignment) then just average the two images using pixel math: (Image1+Image2)/2. Averaging even two similar images provides some noise reduction ( 1/sqrt(2) ), so it's probably worth doing.
Cheers.